Inhibition of Translation by Methylglyoxal
نویسنده
چکیده
Methylglyoxal was a weak inhibitor of translation in the r e t i c u l o c y t e l y s a t e c e l l f r e e system and it did not display cap-dependent inhibition. A similar inhibition was obtained in a wheat-germ cei l f ree system that d i sp layed extensive cap-dependent inhibition with the cap ana logue 7 m e t h y J g u a n o s i n e phosphate . These results show that the chemical reaction of methylglyoxat with 7-methylguanosine is not the mechanism for the inhibition of protein synthesis by methylglyoxal and that methylglyoxat is a weak general inhibitor of translation.
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تاریخ انتشار 2005